GABA Receptor

Gamma-aminobutyric acid Receptor; γ-Aminobutyric acid Receptor

GABA Receptor

Related Products

GABA receptors are a class of receptors that respond to the neurotransmitter gamma-aminobutyric acid (GABA), the chief inhibitory neurotransmitter in the vertebrate central nervous system. There are two classes of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors), whereas GABAB receptors are G protein-coupled receptors (also known asmetabotropic receptors). It has long been recognized that the fast response of neurons to GABA that is blocked by bicuculline and picrotoxin is due to direct activation of an anion channel. This channel was subsequently termed the GABAA receptor. Fast-responding GABA receptors are members of family of Cys-loop ligand-gated ion channels. A slow response to GABA is mediated by GABAB receptors, originally defined on the basis of pharmacological properties.

GABA Receptor Related Products (765)
Antibodies (14)
Related Compound Screening Libraries (1)

By Effects:	Agonists (189)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-105056

Bretazenil	Agonist	99.13%
Bretazenil (Ro 16-6028) is a partial agonist at the gamma-aminobutyric acid A (GABA_A) receptor-linked benzodiazepine site. Bretazenil is potent benzodiazepine examined, exhibiting an IC₅₀ (concentration at which half-maximal inhibition of specific [35S]TBPS binding occurs) of 6.1 nM. Bretazenil shows an EC₅₀ of 10 nM for recombinant α1β1γ2. Anticonvulsant effects.

HY-W105694

3-Aminopropylphosphonic acid	Agonist	98.0%
3-Aminopropylphosphonic acid ((3-Aminopropyl)phosphonic acid) is a phosphonic acid analogue of GABA and a GABA_B receptor agonist.

HY-107482

Picamilon	Agonist	98.25%
Picamilon is an orally active derivative of γ-aminobutyric acid that has nootropic effect. Picamilon improves the epilepsy model in rats and promotes correction of functional disorders of the pancreas during Alloxan (HY-W017227)-induced diabetes mellitus in rats.

HY-101411S

4-Acetamidobutanoic acid-d₃	Agonist
4-Acetamidobutanoic acid-d3 is the deuterated analog of 4-Acetamidobutanoic acid (HY-101411). 4-Acetamidobutanoic acid (N-acetyl GABA), the main metabolite of GABA, exhibits antioxidant and antibacterial activities.

HY-116622

α5IA	Agonist
α5IA (L-822179) is a selective α5 GABAA receptor inverse agonist with neuroprotective potential.

HY-W005749

(R)-4-Amino-3-hydroxybutyric acid	Agonist
(R)-4-Amino-3-hydroxybutyric acid ((R)-GABOB) is a 4-aminobutyric acids (GABAB) agonist. (R)-4-Amino-3-hydroxybutyric acid is promising for research of nervous disorders.

HY-U00315

Gidazepam	Agonist	98.05%
Gidazepam is an agonist of GABA receptor channels (GABA RCs).

HY-19945

DAA-1106	Agonist	99.93%
DAA1106 is a peripheral benzodiazepine receptor (PBR) agonist that is permeable to the blood-brain barrier, but has no affinity for GABAA receptors.

HY-105272

Loreclezole	Agonist	99.97%
Loreclezole, an antiepileptic compound, is a selective GABA_A receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit containing receptors.

HY-113346S

Tetrahydrodeoxycorticosterone-d₃	Agonist	99.53%
Tetrahydrodeoxycorticosterone-d₃ is the deuterium labeled Tetrahydrodeoxycorticosterone. Tetrahydrodeoxycorticosterone, an neurosteroid, is a potent positive allosteric modulator (PAM) of GABAA receptor. Tetrahydrodeoxycorticosterone has potent neuroinhibitory properties.

HY-17599

Piperazine citrate	Agonist	98.0%
Piperazine (1,4-Diazacyclohexane) citrate is a gamma-aminobutyric acid (GABA) agonist. Piperazine citrate is a vital building block and is an essential core in numerous marketed agents with diverse pharmacological activities.

HY-101639A

CP-409092 hydrochloride	Agonist	99.79%
CP-409092 hydrochloride is a partial agonist of GABA_A receptor, with anti-anxiety activity.

HY-103512

TP003	Agonist	98.09%
TP003 is a non-selective benzodiazepine site agonist with EC₅₀s of 20.3, 10.6, 3.24, 5.64 nM for α1β2γ2, α2β3γ2, α3β3γ2, α5β2γ2, respectively. TP003 induces anxiolysis via α2GABA_A receptors.

HY-108068

Alphadolone acetate	Agonist	98.50%
Alphadolone acetate (Alfadolone acetate) is a steroid agent that can suppress or relieve pain, with antinociception.

HY-120837

PZ-II-029	Agonist	99.23%
PZ-II-029 is a GABAA positive allosteric modulator that selectively binds with high affinity to α6β3γ2. PZ-II-029 shows anti-migraine effects.

HY-N13742

Dihydrohonokiol B	Agonist	99.29%
Dihydrohonokiol B (Dihydrohonokiol) is an anxiolytic agent. Dihydrohonokiol B can reduce the neurotoxicity induced by amyloid β protein by stimulating the GABA_C receptor. Dihydrohonokiol B can be used in the research of neurodegenerative diseases such as Alzheimer's disease.

HY-103668A

SSD114 hydrochloride	Agonist	99.13%
SSD114 hydrochloride is a novel GABA_B receptor positive allosteric modulator.

HY-106316

CGS 20625	Agonist	99.80%
CGS 20625 is a potent, selective and orally active partial agonist for the central benzodiazepine receptor. CGS 20625 inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors with an IC₅₀ of 1.3 nM. CGS 20625 enhances GABA in Xenopus laevis oocytes . CGS 20625 can be used for the research of pentylenetetrazol-induced seizures and anxiety.

HY-138014

Cinazepam	Agonist	99.1%
Cinazepam is a partial GABA_A receptor agonist and a benzodiazepine derivative with anxiolytic and sedative properties. Cinazepam can be utilized in research related to sleep disorders.

HY-131941

SJM-3	Agonist
SJM-3 is a positive allosteric modulator of different isoforms of the GABAA receptor. SJM-3 binds at the high-affinity benzodiazepine binding site at the α+/γ- subunit interface.

GABA Receptor Compound Library

Compound library containing various GABA receptor inhibitors and activators.

211compounds HY-L120

Name
Email *

	Sorry, but the email address you supplied was invalid.

GABA Receptor

GABA Receptor

GABA Receptor Related Products (765)

Antibodies (14)

Related Compound Screening Libraries (1)

GABA Receptor Related Products (765):